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ATF4 is a key transcription factor that regulates the expression of... | Download Scientific Diagram

In this process, copper exacerbates oxidative damage by enhancing ROS generation and promoting the overactivation of immune cells, further amplifying local inflammation (2)

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However, given that this is the first pilot study to explore the clinical utility of serum GPX-3 concentration in patients with AAV, we believe that this study has clinical implications in that this identified a novel biomarker that can assess and estimate activity and damage caused by AAV at diagnosis, although confined to the time of diagnosis