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Discovery of Lipid Peroxidation Products Formed in Vivo with a Substituted Tetrahydrofuran Ring (Isofurans) That Are Favored by Increased Oxygen Tension

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Mitochondrial TXNRD2 is an especially promising candidate to overexpress or deplete in mice for aging studies because protein levels and activities in fibroblasts positively correlate with longevity across multiple rodent and primate species [104]