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Capsaicin demonstrates TRPV1-mediated miRNA modulation, with miR-449a significantly upregulated (3–4-fold) in prostate cancer cells, promoting androgen receptor degradation (40–50% reduction) (102)
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We note that if we divide the observed and model trends by the global mean trends and follow the procedure above to adjust the ensemble spread, the magnitude and uncertainty scaling factors change, but the signal-to-noise ratios remain constant
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