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Drosophila circadian repressors like PER accumulate to repress transcriptional activation by the transcription factor complex Clock/Cycle (CLK/CYC), while accumulation of TIM and PER is antagonized, respectively, by light-dependent degradation mediated by the CRY photoreceptor and proteolysis triggered by kinases like Double time (DBT) (Siwicki et al., 2018)
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