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In addition ONOO – reacts directly with carbon dioxide producing nitrosoperoxycarbonate (ONOOCO2 – ), which decomposes into nitrogen dioxide (NO 2 ) and carbonate ( • CO 3 – ) with a reactivity similar to that of OH • radicals [54]

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When B12 deficiency impairs DNA synthesis, the rapidly dividing epithelial cells cannot regenerate effectively, leading to mucosal thinning, increased fragility, and susceptibility to ulceration