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Reactive oxygen species (ROS) with metalloprotease ADAM17 induce the release and transport of Notch intracellular domain (NICD), which in turn translocates into the nucleus and are directly involved in the transcriptional regulation of nuclear target genes that result in fibrotic processes, as proven by the expression of Col-I and αSMA in ectopic lesions of patients with DIE [60]
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SiPhox covers 50 essential biomarkers, from heart health to metabolism, and syncs seamlessly with wearables
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