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This mechanism underpins both systemic analgesia and emerging strategies for local application, where NSAIDs incorporated into wound dressings or hydrogels can exert anti-inflammatory and analgesic effects directly at the site of tissue injury

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During ferroptosis, p53 induces a decrease in the transcription efficiency of XCT via a transcription-dependent mechanism, which leads to a decrease in intracellular cystine intake and a corresponding decrease in the content of synthetic cysteine