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Conditions that should be ruled out include: The other types of Ehlers-Danlos syndrome Other heritable connective tissue disorders such as Marfan syndrome, Loeys-Dietz syndrome, and Stickler syndrome Skeletal dysplasias such as osteogenesis imperfecta Autoimmune rheumatic connective tissue disorders such as lupus and rheumatoid arthritis Chromosomal conditions such as Fragile X syndrome, Kabuki syndrome, and Down syndrome Neuromuscular disorders that can cause joints to become unstable, such as multiple sclerosis and myopathies If these conditions are present but do not explain the person’s symptoms, then hEDS or HSD may also be present