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ADORA2b knockout impairs glycolysis and redox homeostasis in stored murine red blood cells To model mechanisms, we stored RBC from wild-type (WT) and ADORA2B knockout (KO) mice for 0, 7, or 12 days (equivalent to storage of human RBC for 0, 21, and 42 days) (Figure 4A, B)

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Treating with p-coumaric acid inhibited hypothalamic AMPK, but enhanced peripheral AMPK activation [193]