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Larger trials conducted on a broader population would be valuable in confirming these findings and establishing GSH as a neuroprotective agent in clinical practice
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Remarkably, ERβ-, but not ERα-specific ligands, lead to increased phosphorylation of ERK 1/2, which initiates cell cycle entry (demonstrated by the up-regulation of mitotic markers such as CDK1/cdc2 and PCNA), DNA replication, and duplication of the centrosome -the major microtubule-organizing center in the cell- in dividing cells (Wang et al., 2008)
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