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They are generally classified as S1 substances by the World Anti-Doping Agency (WADA)
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When APAP is taken in small doses, most drugs are cleared by sulfation and glucuronidation, and only a tiny amount of drugs can be metabolized by cytochrome P450 enzymes to produce N-acetyl-1,4-benzoquinone imine (NAPQI), which is detoxified by binding to GSH in the liver (van Rongen et al., 2016)
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