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Soares et al., where they revealed HO-1 protective activity on endothelial cells exerted by avoiding cells undergoing TNF-mediated apoptosis, or by means of HO-1 end products, particularly CO, as it was observed that its exogenous administration to endothelial cells in vitro seems to stimulate the cytoprotective processes mediated by HO-1 activation

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DOI:10.1016/j.freeradbiomed.2016.11.033 43