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SemaCagri is blend of two separate peptides administered in one formulation: semaglutide (an analogue of human GLP-1 with extended half-life, modified by C18 fatty acid conjugation and amino acid substitutions at position 8) and cagrilintide (long-acting amylin analog / pramlintide-like peptide with prolonged release kinetics)

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Critically, BPC-157 alone produced no behavioral or temperature effects, confirming it acts only when the serotonin system is disturbed