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Radiolabelled receptor antagonists are also emerging as alternatives in this area [55, 56]

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Reported EC₅₀ values in transfected cell assays sit in the sub-nanomolar to low-nanomolar range at MC1R and MC4R, with roughly an order of magnitude lower potency at MC3R and MC5R, and it is essentially inactive at MC2R, the adrenocorticotropin receptor