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Ligand binding triggers the autocleavage of procaspase-8 into its active form, which initiates downstream caspase activation and the execution of apoptosis
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Overexpression of G6PD increased cellular NADPH levels and upregulated the expression of NOX cofactors, which potentiated ROS production and oxidative damage in mouse pancreatic β cells and thymic lymphoma cells (48, 97)
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