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There are speculations that non-pathogenic commensal microorganisms, which co-evolved with humans, have been a source of immunomodulatory signals for the human body (the “old friends” hypothesis), and now prevent the development of immune-mediated chronic diseases (the “hygiene hypothesis”), with the proper composition of the microbiome promoting the maintenance of the body’s immune balance (the “biodiversity hypothesis”) [1, 39, 53, 54]

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