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These were the non-steroidal anti-inflammatory drugs (NSAIDs) overdose [27,28,29,30,31], insulin overdose seizures [32], neurotoxin cuprizone-induced multiple sclerosis in a rat model [33], and magnesium overdose [34], all as mechanisms of imparting encephalopathies in rats
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Furthermore, in a randomized, double-blind, placebo-controlled study enrolling 70 patients with AD aged 6 to 12 years, the administration of melatonin (6 mg daily) demonstrated to improve SCORAD ( p = 0.007), objective SCORAD ( p = 0.001), serum total IgE levels ( p = 0.005) and Children’s Sleep Habits Questionnaire scores ( p = 0.006) at 6 weeks (40)
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