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Specifically, hypoxia-induced glycolysis in PDAC cells provokes the lactylation of lysine 34 on NUSAP1, a spindle microtubule regulator, which enhances its expression by hindering its degradation, consequently establishing an NUSAP1-LDHA-glycolysis-lactate feedforward loop and facilitating metastasis in PDAC

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Variant:CJC-1295

That does not invalidate the findings, but it does mean independent replication is limited

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