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In the present study, we determine (1) whether co-injections of L-NAC or L-NACme diminish the development of acute physical dependence elicited by injections of fentanyl in male Sprague Dawley rats, as assessed by the withdrawal responses elicited by injection of the μ-OR antagonist, naloxone HCl (NLX), and (2) whether co-injections of L-NAC or L-NACme to rats that are physically-dependent on fentanyl could overcome this dependence, again assessed by the expression of the NLX-precipitated withdrawal responses
